Extensive two step data search was done of multiple data bases such as Google Scholar, the EBSCO Host databases (Psych info, PsycArticles, Medline, PSYNDEX, ERIC) and PubMed. The PRISMA guidelines were used for study selection. Publications in English and German were included. The diagnosis included in the search were Hashimoto thyroiditis, AIT, latent subclinical or overt hypothyroidism. Studies that reported enough data to compute effect sizes were included.
Exclusions included articles in languages other than English or German. Studies that did not include quantitative assessment of depression and anxiety and did not have comparison to a healthy control group were excluded. Studies including pregnant women were also excluded. Study quality was assessed using the Newcastle-Ottawa scale giving a star rating to studies based on quality.
The odds ratio of patients with AIT and anxiety disorders was compared with a healthy control group and the odds ratio of depression in AIT patients was compared with a health control group.