He majored in Biochemistry at Princeton and completed his M.D. at Columbia College of Physicians and Surgeons. Following his internship in general medicine (Passavant Hospital, Northwestern University), he served in the U.S. Army before joining the Special Action Office for Drug Abuse Prevention in Washington D.C. After psychiatric residency at the University of Pennsylvania, he became Assistant Professor at the University of Oklahoma. He subsequently joined the Departments of Psychiatry and later the Department of Clinical Sciences at the University of Texas Southwestern Medical Center at Dallas.
In 2008, he became Vice Dean of Clinical Sciences and Professor at Duke-National University of Singapore. There, he developed several programs designed to advance patient oriented research careers of medical, surgical, mental health, nursing and allied health practitioners including the Academic Medicine Research Institute, the Center for Quantitative Medicine, and the Medical Student III program in clinical research.
His research has focused on the development and testing of innovative treatments for mood disorders including medications, medication combinations, somatic treatments, psychotherapy, and disease management protocols (treatment algorithms). He has authored more than 700 papers and chapters and 10 books. He was Principal Investigator on the NIMH sponsored STAR*D (Sequenced Treatment Alternatives to Relieve Depression) trial and directed the NIMH Depression Trials Network (DTN).
Past awards include the Mood Disorders Research Award (American College of Psychiatrists), the Paul Hoch Award (American Psychopathological Association), the Edward J. Sachar Award (Columbia College P & S), the Nola Maddox Falcone Prize (NARSAD), the American Psychiatric Association Award for Research in Psychiatry, the Gold Medal Award (Soc. Biological Psychiatry, and the Donald Klein Lifetime Research Award (American Society of Clinical Psychopharmacology). He has served as President of the Society of Biological Psychiatry and Society for Psychotherapy Research. Thomas Reuters named him as one of the ”World’s Most Influential Scientific Minds “in 2014
He presently provides consultation to academic, governmental and industrial organizations.
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