Side effects of antidepressants are clinically important and have a huge effect on whether patients continue to take the antidepressant.
However, our ability to predict who is more likely to have side effects on an antidepressant is quite limited.
This study aimed to assess whether depressed patients with comorbid panic disorder were more likely to experience side effects than those without panic disorder.
It also assessed whether a greater burden of side effects in patients with both depression and panic disorder predicted a poorer outcome for these patients.
Lastly, the study also examined the relationship between reporting side effects attributed to an antidepressant and having comorbid social phobia or generalized anxiety disorder. This was done in order to see whether the increased risk of side effects was specific to comorbid panic disorder or present with any comorbid anxiety disorder.